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JAKAVI demonstrated superior results to best available therapy1

Significantly more patients receiving JAKAVI met the primary composite endpoint compared with those receiving BAT1,2

Primary response at Week 321-3

Significantly more Polycythemia Vera patients receiving JAKAVI,  a JAK2 inhibitor, met the primary composite endpoint compared with those receiving BAT

Haematocrit control was defined as the absence of phlebotomy eligibility from Week 8 to Week 32, with no more than one post-randomisation phlebotomy allowed prior to Week 8. Phlebotomy eligibility was defined as haematocrit >45% and ≥3% higher than the baseline or >48%, whichever was lower.1,2 Spleen response was defined as ≥35% reduction from baseline in spleen volume, as assessed by MRI or CT.1,2

  • Among patients who achieved a primary response, 91% had a durable response at Week 481,2
    • Durability of primary response at Week 48 was a key secondary endpoint1,2

77% of patients receiving JAKAVI met at least one component of the primary endpoint1,2

Next: JAKAVI helps patients attain durable haematocrit control

BAT=best available therapy; CT=computed tomography; HCT=haematocrit; MRI=magnetic resonance imaging.


  1. Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372(5):426-435.
  2. JAKAVI® (ruxolitinib) tablets: EU Summary of Product Characteristics. Novartis; May 2019.
  3. Data on file. Novartis Pharma AG. Basel, Switzerland.