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JAKAVI demonstrated comprehensive haematologic control1,2

Significantly more patients receiving JAKAVI achieved complete haematologic remission (CHR) compared with those in the BAT arm1,2

  • JAKAVI enabled more than twice as many patients to achieve CHR1,2

CHR at Week 321-3

JAKAVI enabled more than twice as many Polycythemia Vera patients to achieve complete haematologic remission (CHR)

CHR was defined as having achieved all of the following: haematocrit control, platelet count ≤400 x 109/L, and leukocyte count ≤10 x 109/L.1

  • CHR was a key secondary endpoint1

88.5% of patients who achieved CHR at Week 32 maintained CHR at Week 484
Durability of CHR at Week 48 was a secondary endpoint3

JAKAVI helped control multiple key blood counts1-3

Control rates of key haematologic parameters at Week 321-3

JAKAVI, a JAK2 inhibitor, helped control multiple key blood counts in Polycythemia Vera patients

Haematocrit control was defined as the absence of phlebotomy eligibility, with no more than one post-randomisation phlebotomy allowed prior to Week 8. Phlebotomy eligibility was defined as haematocrit >45% and ≥3% higher than baseline or >48%, whichever was lower.1,2 Leukocyte control and platelet control as components of CHR were defined as ≤10 x 109/L and ≤400 x 109/L, respectively.1

  • The measures shown are the individual components of CHR, which was a key secondary endpoint1

Next: QoL improvements seen with JAKAVI treatment

BAT=best available therapy.


  1. Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372(5):426-435.
  2. JAKAVI® (ruxolitinib) tablets: EU Summary of Product Characteristics. Novartis; May 2019.
  3. Data on file. Novartis Pharma AG. Basel, Switzerland.
  4. Vannucchi AM, Kiladjian J-J, Griesshammer M, et al. Ruxolitinib proves superior to best available therapy in a prospective, randomized, phase 3 study (RESPONSE) in patients with polycythemia vera resistant to or intolerant of hydroxyurea. Paper presented at: 19th Congress of EHA; June 12-15, 2014; Milan, Italy.