PV is a trilineage disease
PV is a myeloproliferative disorder characterised by trilineage haematopoietic cell growth1,2
- PV is characterised by excessive erythrocytosis and elevated white blood cell (WBC) and platelet counts2
Uncontrolled trilineage proliferation drives thrombotic complications1-4

Excessive myeloproliferation results in multiple physiologic effects associated with increased risk and burden of disease5
The risks and burden of PV5

The PV diagnostic criteria highlight the trilineage characteristics of PV6
Overactive JAK pathway signalling drives the pathogenesis of PV8-10
Pathogenesis of PV

- Overactive JAK signalling results in trilineage proliferation and can increase production of inflammatory cytokines8-10
- Almost all patients (>99%) with PV harbor a mutation in the JAK2 gene11