The majority of PV patients experience symptoms
Patients with PV experience a broad range of burdensome symptoms1
Prevalence of symptoms in PV1

- PV symptoms can significantly impair quality of life (QoL), resulting in clinically deficient QoL nearly as frequently as in myelofibrosis (38% vs 42%)2
Pruritus and fatigue are among the most common symptoms of PV1
- Among patients with PV who experience pruritus:
- 15% characterise the symptom as “unbearable” (rating of 6 on a scale of 6)3
- 51% report that pruritus is the same or worse after conventional PV therapy3
- Patients with pruritus experience significantly worse QoL (P=0.0007) than patients with no pruritus3
- Fatigue was reported regardless of disease severity, occurring in patients who lacked complications of PV, such as thrombosis or splenomegaly4
Symptoms can occur independently of blood values, disease duration, and myelosuppressive treatment5