Myelofibrosis is associated with severe, frequent symptom burden1
Progressive, relentless symptoms impair QoL and increase disability2-4
- MF-related symptoms compromise social functioning, physical activity, independence, and QoL1,5
- Constitutional MF symptoms negatively impact QoL and are associated with poor prognosis for survival4,6
- Fatigue is extremely common and is similar to or worse than that suffered by patients undergoing chemotherapy for haematologic malignancies7
Adapted from: Scherber R et al. Blood. 2011;118:401-408.1
QoL scores for MF patients were worse than those for all cancer patients combined8
Adapted from: Kiladjian J et al. Poster presented at ASCO Annual Meeting, 2012.8
MF-related symptoms are progressive and may worsen even with conventional therapies9,10
Adapted from: Verstovsek S et al. N Engl J Med. 2012;366:799-807.9
Symptoms measured with the use of a modified Myelofibrosis Symptom Assessment Form (MFSAF), version 2.0.
Adapted from: Harrison C et al. N Engl J Med. 2012;366:787-798.10
Symptoms measured by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core model.